Contact

Department

Pediatrics

Trevi A. Mancilla

Graduate Student

Personal Statement:

Program:
IBMS Physiology and Pharmacology Discipline

Lab Association:
Greg Aune, M.D., Ph.D.

Hobbies and Interests:
Cycling, STEM outreach and science literacy, mixology, raising son and daughter


Education

BA, Biochemistry
Minor, Religion
Wellesley College - Wellesley, Massachusetts

Research

Dr. Aune’s lab focuses on the late complications of chemotherapy and radiation in pediatric cancer survivors. One key effort is aimed at elucidating the early mechanisms that lead to congestive heart failure in these patients decades after treatment. Existing research has primarily focused on deleterious effects of doxorubicin (a chemotherapy agent known to cause heart disease) on cardiac myocytes. My work examines the effects of doxorubicin on the cardiac fibroblast, a significant support cell of the heart. Just as doxorubicin can cause mitochondrial toxicity in myocytes, we hypothesize that it will also cause mitochondrial toxicity in fibroblasts leading to persistent cellular dysfunction of this very important support cell.

Awards & Accomplishments

Cardiovascular Outreach Award, Council on Basic Cardiovascular Sciences – BCVS 2016 Scientific Sessions – June 2016
University Hospital Pediatrics Research Day – 2nd place winner for poster presentation – May 2016
Minority Travel Fellowship Award – American Physiological Society – Experimental Biology 2016 – Jan 2016
Minority Travel Award – American Heart Association – Basic Cardiovascular Section to Scientific Sessions – Sept 2015
University Hospital Pediatrics Research Day – 1st place winner for poster presentation – May 2015
Greehey Scholar – 2012-2014
Commitment to Community Award – University Hospital System Family and Community Medicine – 2012-2013
15th Annual Department of Medicine Research Day Award – Resident/Student category winner – May 2012

Affiliations

2015-Present – Member, American Physician Scientist Association
2015-Present – Member, American Physiology Society
2015-Present – Member, Council of Basic Cardiovascular Sciences, American Heart Association
2015-Present – Founder & Co-organizer, Physiology Trainee Luncheon series, UTHSCSA
2014-2105 – Member, Physiology Student Symposium Committee, UTHSCSA
2012-2013 – Organizer, MD/PhD Annual Conference, UTHSCSA
2012-2013 – Member, MD/PhD Student Council, UTHSCSA
2012-2013 – Membership chair, Latino Medical Student Association, Southwest Region
2012-2014 – Member, Latino Medical Student Association, UTHSCSA

Publications

• Books and Publications •

Ramirez, TA., Iver, RP, Ghasemi, O., Lopez, EF., Levin, DB., Zhang, J., Zamilpa, R., Chou, YM., Jin, YF., Lindsey, ML. (2014) Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects J Mol and Cell Cardiol. Jul;72:326-35

Halade, GV., Ma, Y., Ramirez, TA., Zhang, J., Dai, Q., Hensler, JG., Lopez, EF., Ghasemi, O., Jin, YF., Lindsey, ML. (2013) Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice Am J of Physiol Heart Circ Physiol Dec;305(12):H1830-42

de Castro Brás, LE., Ramirez, TA., DeLeon, KY., Chiao, YA., Ma, Y., Dai, Q., Halade, GV., Hakala, KW., Weintraub, ST., Lindsey, ML. (2013) Texas 3-Step Decellularization Protocol: Looking at the Cardiac Extracellular Matrix J Proteomics Jun 28;86:43-52. doi: 10.1016/j.jprot.2013.05.004

Ramirez, TA., Jourdan-LeSaux, C., Joy, A., Zhang, J., Dai, Q., Mifflin, S., Lindsey, ML. (2012) Chronic and Intermittent Hypoxia Differentially Regulate Left Ventricular Inflammatory and Extracellular Matrix Responses Hypertens ResearchAug;35(8):811-8

Chiao, YA., Ramirez, TA., Jin, YF., Zamilpa, R., Okoronkwo, SM., Dai, Q., Lindsey, ML. (2012) Matrix Metalloproteinase-9 Deletion Attenuates Myocardial Fibrosis and Diastolic Dysfunction in Aging Mice Cardiovasc ResDec 1;96(3):444-55

Ghasemi, O., Nguyen, N., Ramirez, TA., Zhang, J., Lindsey, ML., Jin, YF. (2012) A biclustering approach to analyze drug effects on extracellular matrix remodeling post-myocardial infarction. 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, 143-150. Doi: 10.1109BIBMW.2012.6470296

Zamilpa, R., Ibarra, J., de Castro Bras, LE., Ramirez, TA., Nguyen, N., Halade, GV., Zhang, J., Dai, Q., Lowell, W., Ahuja, SS., D’Armiento, J., Jin, YF., Lindsey, ML. (2012) Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction J Mol Cell Cardiol Nov;53(5):599-608

Ma, Y., Halade, GV., Zhang, J., Ramirez, TA., Levin, D., Voorhees, A., Jin, YF., Han, HC., Manicone, AM., Lindsey, ML. (2012) Matrix Metalloproteinase-28 Deletion Exacerbates Cardiac Dysfunction and Rupture Following Myocardial Infarction in Mice by Inhibiting M2 Macrophage Activation Circ Res. Feb 15;112(4):675-88

• Grants, Funding and Research Support •

National Center for Advancing Translational Sciences – National Institutes of Health – Grant TL1 TR001119

• Lectures, Posters and Presentations •

UTHSCSA Department of Pediatrics Research Day – San Antonio, TX. – May 2015

Ramirez, TA., Andrews, TG., Aune, GJ. Fibrosis in the Murine Myocardium following Doxorubicin Exposure (Poster)

Federation of American Societies for Experimental Biology Journal (FASEB J) Conference – March 2012

Ramirez, TA., Jourdan-LeSaux, C., Joy, A., Zhang, J., Dai, Q., Mifflin, S., Lindsey, ML. Chronic and Intermittent Hypoxia Differentially Regulate Left Ventricular Inflammatory and Extracellular Matrix Responses (Poster)

Federation of American Societies for Experimental Biology Journal (FASEB J) Conference – March 2012

Ma, Y., Zhang, J., Ramirez, TA., Manicone, AM., Lindsey, ML. Matrix metalloproteinase-28 Deletion Attenuates Short-term Left Ventricular Dysfunction but Exacerbates Cardiac Rupture Post-Myocardial Infarction in Mice (Oral Presentation)

Federation of American Societies for Experimental Biology Journal (FASEB J) Conference – March 2012

Halade, GV., Ramirez, TA., Zhang, J., Hensler, JG., Jin, Y-F., Lindsey, ML. Brain-Derived Neurotrophic Factor Intensifies the Early Inflammatory Response After Myocardial Infarction (Oral Presentation)

Federation of American Societies for Experimental Biology Journal (FASEB J) Conference – March 2012

Zamilpa, R., Ramirez, TA., Dai, Q., Dayah, T., Nguyen, N., Zhang, J., Ahuja, SS., D’Armiento, J., Jin, Y-F. and Lindsey, ML. MMP-9 overexpression in macrophages regulates the post-myocardial infarction inflammatory response through SCYE1 (Oral Presentation)