Contact

Department

Pharmacology

Samantha Yee

Graduate Student

Personal Statement:

Program:
IBMS Physiology and Pharmacology Discipline

Lab Association:
April Risinger, Ph.D.

Hobbies and Interests:

Community outreach, working out, dancing, ice skating and breast and ovarian cancer research


Education

B.S. in Biology, Minor in Chemistry, St. Lawrence University, Canton, NY

Research

My current research focuses on evaluating the pharmacological and physiological effects of a novel class of microtubule stabilizers, the taccalonolides, in both in vitro and in vivo cancer models. The taccalonolides are natural products that have superior efficacy to clinically approved microtubule targeting agents in drug-resistant tumor models, as a result of its covalent interaction with tubulin that promotes distinct effects on the microtubule polymer. Ultimately, the goals of my work are 1) to identify an optimal taccalonolide for future clinical development and 2) elucidate the molecular and cell biological mechanisms underlying the antitumor efficacy of this novel class of drugs.

Publications

Sreelatha, Anju, Yee, Samantha S., Lopez, Victor A., Park, Brenden C., Kinch, Lisa, Pilch, Sylwia, Servage, Kelly A., Zhang, Junmei, Jiou, Jenny, Karasiewicz, Monika, Lobocka, Malgorzata, Grishin, Nick, Orth, Kim, Kucharczyk, Roza, Pawlowski, Krzysztof, Tomchick, Diana R., Tagliabracci, Vincent S. Protein AMPylation by an evolutionarily conserved pseudokinase. Cell. 10.1016/j.cell.2018.08.046: https://www.cell.com/cell/pdf/S0092-8674(18)31107-3.pdf

Nguyen, Kim B., Sreelatha, Anju, Durrant, Eric S., Lopez-Garrido, Javier, Muszewska, Anna, Dudkiewicz, Malgorzata, Grynberg, Marcin, Yee, Samantha, Pogliano, Kit, Tomchick, Diana R., Pawlowski, Krzysztof, Dixon, Jack E., Tagliabracci, Vincent S. Phosphorylation of spore coat proteins by a family of atypical protein kinases. Proc Natl Acad Sci. 2016 May 16: http://www.pnas.org/content/early/2016/05/11/1605917113.full.pdf