Contact

Location: STRF 208.2

Department

Cellular and Integrative Physiology

Martin Paukert, M.D.

Assistant Professor

Education

Eberhard Karls University of Tübingen, Germany (M.D.)
The Johns Hopkins University School of Medicine (Postdoc)

Research

The Paukert Lab is interested in the role of neuron-astroglia interaction in neuromodulation. Astroglia are recognized for their homeostatic support functions during neuronal activity. Much less is known about how astroglia modulate neuronal activity in a behavioral state-dependent manner. A particular focus of our work lies on understanding molecular events and behavioral context leading to astroglia Ca2+ dynamics in awake mice, consequences for neuronal signaling and alterations of these signals in transgenic mouse models of neurodegenerative and neurobehavioral disease. We are pursuing these goals combining behavioral manipulations, such as employing a motorized treadmill to monitor and control the state of arousal, with two-photon microscopy and electrophysiology to observe activity of ensembles of neurons and astroglia with cellular resolution.

Lab Members

 John Cavaretta
Research Assistant – Senior
Graduate Student
Graduate Student
Graduate Student
Postdoctoral Fellow
Graduate Student
Graduate Student
 Liang Ye
Postdoctoral Fellow
 Xiangyu Zhu
Student Associate

Publications

Norepinephrine controls astroglial responsiveness to local circuit activity.

Paukert, M., Agarwal, A., Jaepyeong, C., Doze, V.A., Kang, J.U. and Bergles, D.E., Neuron82(6): 1263-1270, 2014.

Reduction of motion artifacts during in vivo two-photon imaging of brain through heartbeat triggered scanning.

Paukert, M. and Bergles, D.E., Journal of Physiology 590(Pt 13): 2955-2963, 2012.

Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum.

Paukert, M., Huang, Y.H., Tanaka, K., Rothstein, J.D. and Bergles, D.E., Journal of Neuroscience 30: 7290-7299, 2010.