Seminar Speaker – Julio Ayala, Ph.D.

Event Date & Time

March 4, 2019

Location

444B


Event Details:

Julio E. Ayala, Ph.D.
Associate Professor
Molecular Physiology and Biophysics
Vanderbilt University

“Glucagon-like peptide-1 and body weight loss: expected and unexpected mechanisms.”

Videoconference to AT&T 1.120

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About the Speaker(s)

Research in the Ayala lab focuses on gut‐brain interactions that play a role in the maintenance of energy balance. Specifically, our lab is interested in defining how the gut hormone glucagon‐like peptide‐1 (Glp1) and therapeutic Glp1 receptor (Glp1r) agonists engage the central nervous system to regulate caloric intake and expenditure. We combine targeted genetic and pharmacological interventions with state‐of‐the‐art in vivo metabolic phenotyping approaches to elucidate brain regions and molecular mechanisms that mediate the effects of Glp1r agonists on energy balance as well as reward and motivated behaviors. These approaches are being leveraged towards the design of more effective Glp1‐based drugs for the treatments of type 2 diabetes and obesity.