Seminar Series – Jenny Hsieh, Ph.D.

The work in the Hsieh laboratory focuses on deciphering the mechanisms that regulate neural stem cells and neurogenesis in the mammalian brain. We hope to use neural stem cells to understand the cellular and molecular mechanisms underlying epileptogenesis and develop novel strategies to treat or prevent epilepsy and other neurological disorders, such as Alzheimer’s disease and stroke. We continue to make significant contribution to understanding the role of epigenetic and transcriptional regulation in adult neurogenesis. In my talk today, I will discuss using human induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 gene editing technology as approaches to understand mechanisms underlying brain disorders. I will explore how our lab and other labs can making ARX patient-derived iPSC lines and CRISPR/Cas9 to make isogenic lines.