Selected Publications

Khatri A, Weiss DSThe role of Loop F in the activation of the GABA receptor. J Physiol. 2010 Jan 1;588(Pt 1):59-66.

Li P, Khatri A, Bracamontes J, Weiss DS, Steinbach JH, Akk G. Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids. Mol Pharmacol. 2010 Apr;77(4):539-46.

Khatri A, Sedelnikova A, Weiss DS.  Sructural Rearrangements in Loop F of the GABA Receptor Signal LIgand Binding, Not Channel Activation.  Biophys J. 2009 Jan:96(1):45-55.

Zheleznova NN, Sedelnikova A, Weiss DS. Function and modulation of delta-containing GABA(A) receptors.Psychoneuroendocrinology. 2009 Sep 17.

Erkkila, BE., Sedelnikova, AV, Weiss, DS. Stoichiometric pore mutations of the GABAAR reveal a pattern of hydrogen bonding with picrotoxin. Biophys J. 2008 Feb 29.

Zheleznova N, Sedelnikova A, Weiss, DS. alpha(1)beta(2)delta, a silent GABA(A) receptor: recruitment by tracazolate and neurosteroids. Br J Pharmacol. 2008 Mar;153(5):1062-71. 

Campo-Soria C, Chang Y, Weiss DS. Mechanism of action of benzodiazepines on GABAA receptors. Br J Pharmacol. 2006 Aug;148(7):984-90.

Sedelnikova A, Erkkila BE, Harris H, Zakharkin SO, Weiss DS. Stoichiometry of a pore mutation that abolishes picrotoxin-mediated antagonism of the GABAA receptor. J Physiol. 2006 Dec 1;577(Pt 2):569-77. 

Sedelnikova A, Smith CD, Zakharkin SO, Davis D, Weiss DS, Chang Y. Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model. J Biol Chem. 2005 Jan 14;280(2):1535-42. 

Filippova N, Wotring VE, Weiss DSEvidence that the TM1-TM2 Loop Contributes to the ρ1 GABA Receptor Pore. J Biol Chem. 2004 May 14;279(20):20906-14. 

Wotring, V.E., Miller, T.S., and Weiss, D.S. Mutations at the GABA receptor selectivity filter: a possible role for effective charges. Journal of Physiology 548:527-540, 2003. 

Weiss, D.S., and Chang, Y. Crystallizing our understanding of partial agonists. Nature Neuroscience. 2003 Aug;6(8):788-9, Aug 2003. 

Chang, Y.C., Ghansah, E., Chen, Y., Ye, J., Weiss, D.S. Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function. Journal of Neuroscience. 22, 7982-7990, 2002.

Chang, Y. and Weiss, D.S.. Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism. . Nature Neuroscience. 5, 1163-1168, 2002.

Chang, Y. and Weiss, D.S. Channel opening locks agonist onto the GABAC receptor. Nature Neuroscience.2(3) 219-225, 1999. 

Filippova, N., Dudley, R. and ,Weiss, D.S. Evidence for phosphorylation-dependent internalization of recombinant human GABAC receptors. Journal of Physiology. 518.2, 385-399, 1999.

Amin, J. And Weiss, D. S. Insights into the activation mechanism of rho1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits. Proceedings of the Royal Society of London.263:272-282, 1996.

Chang, Y., Wang, R., Barot, S. And Weiss, D.S., Stoichiometry of a recombinant GABA receptor, Journal of Neuroscience. 16:5415-5424, 1996.