Selected Publications

Toney GM, Vallon V, Stockand JDIntrinsic control of sodium excretion in the distal nephron by inhibitory purinergic regulation of the epithelial Na(+) channel. Curr Opin Nephrol Hypertens. 2012 Jan;21(1):52-60. Review. PMID: 22143248 [PubMed - indexed for MEDLINE

Kucher V, Boiko N, Pochynyuk O, Stockand JDVoltage-dependent gating underlies loss of ENaC function in Pseudohypoaldosteronism type 1. Biophys J. 2011 Apr 20;100(8):1930-9. PMID: 21504729 [PubMed - indexed for MEDLINE]


Bugaj V, Mironova E, Kohan DE, Stockand JDCollecting duct-specific endothelin B receptor knockout increases ENaC activity. Am J Physiol Cell Physiol. 2012 Jan;302(1):C188-94. Epub 2011 Sep 14. PMID: 21918182 [PubMed - indexed for MEDLINE]

Mironova E, Peti-Peterdi J, Bugaj V, Stockand JDDiminished paracrine regulation of the epithelial Na+ channel by purinergic signaling in mice lacking connexin 30. J Biol Chem. 2011 Jan 14;286(2):1054-60. Epub 2010 Nov 12. PMID: 21075848 [PubMed - indexed for MEDLINE]


Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V.Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J. 2010 Jan 22.

Bugaj V, Pochynyuk O, Stockand JDActivation of the epithelial Na+ channel in the collecting duct by vasopressin contributes to water reabsorption. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1411-8.

 Dorofeeva NA, Karpushev AV, Nikolaev MV, Bolshakov KV, Stockand JD, Staruschenko A. Muscarinic M1 modulation of acid-sensing ion channels.Neuroreport. 2009 Sep 1.

Pochynyuk O, Bugaj V, Vandewalle A, Stockand JDPurinergic control of apical plasma membrane PI(4,5)P2 levels sets ENaC activity in principal cells. Am J Physiol Renal Physiol. 2008 Jan;294(1):F38-46

Stockand JD, Staruschenko A, Pochynyuk O, Booth RE, Silverthorn DU. Insight toward epithelial Na+ channel mechanism revealed by the acid-sensing ion channel 1 structure. IUBMB Life. 2008 Sep;60(9):620-8

Bugaj V, Pochynyuk O, Mironova E, Vandewalle A, Medina JL, Stockand JDRegulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct. Am J Physiol Renal Physiol. 2008 Oct;295(4):F1063-70.

Pochynyuk O, Bugaj V, Stockand JDPhysiologic regulation of the epithelial sodium channel by phosphatidylinositidesCurr Opin Nephrol Hypertens. 2008 Sep;17(5):533-40.

Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JDParacrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone.
J Biol Chem. 2008 Dec 26;283(52):36599-607.

Staruschenko A, Pochynyuk O, Vandewalle A, Bugaj V, Stockand JDAcute Regulation of the Epithelial Na+ Channel by Phosphatidylinositide 3-OH Kinase Signaling in Native Collecting Duct Principal Cells. J Am Soc Nephrol. 2007 Jun;18(6):1652-61.

Staruschenko A, Dorofeeva NA, Bolshakov KV, Stockand JDSubunit-dependent cadmium and nickel inhibition of acid-sensing ion channels. Dev Neurobiol. 2007 Jan;67(1):97-107.

Pochynyuk O, Tong Q, Medina J, Vandewalle A, Staruschenko A, Bugaj V, Stockand JDMolecular determinants of PI(4,5)P2 and PI(3,4,5)P3 regulation of the epithelial Na+ channel. J Gen Physiol. 2007 Oct;130(4):399-413.

Pochynyuk O, Stockand JD, Staruschenko A. Ion channel regulation by Ras, Rho, and Rab small GTPases.Exp Biol Med (Maywood). 2007 Nov;232(10):1258-65. Review

Pochynyuk O, Tong Q, Staruschenko A, Ma HP, Stockand JD.  Regulation of the epithelial Na+ channel (ENaC) by phosphatidylinositides.  Am J Physiol Renal Physiol. 2006 May;290(5):F949-57.

Pochynyuk O, Medina J, Gamper N, Genth H, Stockand JD, Staruschenko A. Rapid translocation and insertion of the epithelial Na+ channel in response to RhoA signaling.  J Biol Chem. 2006 Sep 8;281(36):26520-7.

Staruschenko A, Booth RE, Pochynyuk O, Stockand JD, Tong Q. Functional reconstitution of the human epithelial Na+ channel in a mammalian expression system. Methods Mol Biol. 2006;337:3-13.

Staruschenko A, Dorofeeva NA, Bolshakov KV, Stockand JDSubunit-dependent cadmium and nickel inhibition of acid-sensing ion channels. J Neurobiol. 2006 Dec 1;67(1):97-107.

Pochynyuk O, Tong Q, Staruschenko A, Stockand JDBinding and direct activation of the epithelial Na+ channel 

Tong Q, and Stockand JDReceptor tyrosine kinases mediate epithelial Na(+) channel inhibition by epidermal growth factor.  Am J Physiol Renal Physiol. 2005 Jan;288(1):F150-61.

Stockand JDPreserving salt: in vivo studies with Sgk1-deficient mice define a modern role for this ancient protein. Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R1-3.

Gamper N, Stockand JD, and Shapiro MS. The use of Chinese hamster ovary (CHO) cells in the study of ion channels. J Pharmacol Toxicol Methods. 2005 May-Jun;51(3):177-85.


Staruschenko A, Pochynyuk OM, Tong Q, and Stockand JDRas couples phosphoinositide 3-OH kinase to the epithelial Na+ channel. Biochim Biophys Acta. 2005 May 20;1669(2):108-15. 

Staruschenko A, Adams E, Booth RE, and Stockand JDEpithelial Na+ channel subunit stoichiometry.Biophys J. 2005 Jun;88(6):3966-75.

Tong Q, Menon AG, and Stockand JDFunctional polymorphisms in the {alpha}-subunit of the human epithelial Na+ channel increase activity. Am J Physiol Renal Physiol. 2005 Oct 25. 

Pochynyuk O, Staruschenko A, Tong Q, Medina J, and Stockand JDIdentification of a functional phosphatidylinositol 3,4,5-trisphosphate binding site in the epithelial Na+ channelBiol Chem. 2005 Nov 11;280(45):37565-71.

Staruschenko A, Pochynyuk O, and Stockand JD.Regulation of epithelial Na+ channel activity by conserved serine/threonine switches within sorting signals. J Biol Chem. 2005 Nov 25;280(47):39161-7. 

Bhalla V, Daidie D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O,and Pearce D. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Mol Endocrinol. 2005 Dec;19(12):3073-84

Staruschenko A, Nichols A, Medina JL, Camacho P, Zheleznova NN, and Stockand JDRho small GTPases activate the epithelial Na(+) channel. J Biol Chem. 2004 Nov 26;279(48):49989-94.