Selected Publications

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies.
Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R.
Aging Dis. 2017 May 2;8(3):257-266. doi: 10.14336/AD.2017.0112. eCollection 2017 May.
PMID: 28580182

mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment.
Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V.
J Cereb Blood Flow Metab. 2017 Jan 1:271678X17705973. doi: 10.1177/0271678X17705973. [Epub ahead of print]
PMID: 28511572

Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease.
Galvan V, Hart MJ.
Biochim Biophys Acta. 2016 May;1862(5):992-1007. doi: 10.1016/j.bbadis.2015.11.010. Epub 2015 Nov 27.
PMID: 26639036

Lin A, Halloran JJ, Burbank RR, Korde S, Zheng W, Hussong SA, Podlutskaya N, Strong R, Richardson A, Hart MJ, Fox PT, Lechleiter J, Galvan V (2013). Chronic rapamycin restores brain vascular density and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease. J Cereb Blood Flow Metab. Jun 26. PMID: 23801246.

Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease.
Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V.
J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21. doi: 10.1038/jcbfm.2013.82. Epub 2013 Jun 26.
PMID: 23801246

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice.
Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V.
Neuroscience. 2012 Oct 25;223:102-13. doi: 10.1016/j.neuroscience.2012.06.054. Epub 2012 Jun 28. Erratum in: Neuroscience. 2015 Oct 15;306():151. 
PMID: 22750207

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.
Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V.
J Neurochem. 2013 Mar;124(6):880-93. doi: 10.1111/jnc.12080. Epub 2012 Dec 26.
PMID: 23121022

Halloran JJ, Hussong S, Podlutskaya N, Burbank R, Austad S, Hart MJ, Fischer K and Galvan V. (2012) Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neurosci. June 28. PMID: 22750207.

Pierce A, Podlutskaya NP, Halloran JJ and Galvan V (2012) Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease. J Neurochem. December 26. DOI: 10.1111/jnc.12080. View Editorial Highlight.

Lin A, Halloran JJ, Burbank RR, Korde S, Zheng W, Hussong S, Podlutskaya N, Strong R, Richardson A, Fox PT, Lechleiter J, Hart MJ, Galvan V (2012) Chronic rapamycin restores brain vascular integrity through eNOS activation and improves memory in mice modeling Alzheimer’s disease. J Cereb Blood Flow and Metab. In review.

Zhang J, Rao R, Spilman P, Mangada J, Xie L, Vitelli C, Gorostiza OF, Madden DT, Zeng X, Jin K, Hart MJ, Bredesen DE and Galvan V (2011) Endogenously EGFP-Labeled Mouse Embryonic Stem Cells. Aging and Dis. 2:18-29.
 

Hart MJ, Sharma MK, Liu M, Cuny GD, Glicksman MA and Galvan V (2011) A highly-sensitive high-throughput screen targeting caspase 8-mediated cleavage of the amyloid precursor protein. Analytical Biochemistry. 421:467-76.
 

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V.
PLoS One. 2010 Apr 1;5(4):e9979. doi: 10.1371/journal.pone.0009979. Erratum in: PLoS One. 2011;6(11). doi:10.1371/annotation/05c1b976-7eab-4154-808d-0526e604b8eb. 
PMID: 20376313

Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Richardson A, Strong R and Galvan V (2010) Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 5:e9979.

Calheiros F, Galvan V, Corset V, Llambi F, Bredesen DE, and Mehlen P. (2009) Netrin-1 acts as an amyloid precursor protein ligand and suppresses amyloid-ß production. Cell Death Differ. 16:655-63.
 

Jin K, Mao X, Xie L, Galvan V, Lai B, Wang Y, Gorostiza O, Wang X, Greenberg D. (2009) Transplantation of human neural precursor cells in matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow and Metab. Oct 14. PMID: 19826433.
 

Vogt DL, Thomas D, Liang M, Galvan V, Bredesen DE, Lamb BT and Pimplikar SW. (2009) Abnormal neuronal networks and seizure susceptibility in transgenic mice overexpressing the APP intracellular domain. Neurobiol Aging. Oct 12. PMID: 19828212.
 

Zhang J, Gorostiza O, Tang H, Bredesen DE, Galvan V (2009) Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience. Beh Brain Res 206:202-07.
 

Nguyen T, Galvan V, Zhang J, Bredesen DE. (2008) p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem 104: 1065-80.
 

Galvan V, Zhang J, Gorostiza O, Tang H, Huang W, Banwait S, Ataie M, Bredesen DE. (2008) Long-term prevention of Alzheimer’s disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Beh Brain Res. 191:246-55.
 

Tang H, Wang Y, Xie L, Mao X, Won SJ, Galvan V, Jin K. (2007) Effect of neural precursor proliferation level on neurogenesis in rat brain during aging and after focal ischemia. Neurobiol Aging 104:1065.
 

Galvan V, Banwait S, Spilman PR, Gorostiza OF, Peel A, Sidhu G, Tang, H, Ichijo H and Bredesen DE. (2007) Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol dis. 28:65-75.
 

Semenov I, Wang B, Herlihy JT, Brenner R. BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L802-10.
 

Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF. (2006) Deficits in synaptic transmission and learning in APP transgenic mice require C-terminal cleavage of APP. J Neurosc. 26:13428.
 

Wang Y, Galvan V, Gorostiza O, Ataie M, Jin K and Greenberg D. (2006) Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat. Brain Res 1115:186-93.
 

Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE. (2006) Reversal of Alzheimer’s-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natll Acad Sci USA. 103:7130-35.
 

Jin K, Galvan V, Xie L, Mao XO, Gorostiza OF, Bredesen DE, Greenberg D. (2004) Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A. 101: 13363-67.

Galvan V, Kurakin A. and Bredesen DE. (2003) Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis. FEBS Letters 558: 57-62.

Galvan V, Logvinova A, Sperandio S, Ichijo H and Bredesen DE. (2003) Type 1 Insulin-like growth factor receptor (IGF-IR)signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J Biol Chem. 278:13325.
 

Ikeno Y, Hubbard GB, Lee S, Yu BP, Herlihy JT. The influence of long-term aloe ingestion on age-related disease in male Fischer 344 rats. Phytother. Res. Phytother Res. 16(8):712-8, Dec 2002.
 

Klebanov S, Herlihy JT, Freeman GL. Assessing effects of long-term food restriction on myocardial energetics in the isolated heart preparation. Mech Ageing Dev;123(10):1375-88, Jul 2002.
 

Ikeno Y, Hubbard GB, Lee S, Yu BP, Herlihy JT. The influence of long-term Aloe vera ingestion on age-related disease in male Fischer 344 rats. Phytother Res. 2002 Dec;16(8):712-8.
 

Galvan V, Chen S, Lu D, Koo EH and Bredesen DE. (2002) Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem. 82: 283-4.
 

Kim JW, Back BS, Kim YK, Herlihy JT, Ikeno Y, Yu BP, Chung HY. Gene expression of cyclooxygenase in the aging heart. J. Gerontol. 56: B350-B355, 2001.
 

Kim YK, Herlihy JT. Mechanism of sodium nitroprusside (SNP) action on ischemia-reperfusion (IR). FASEB J. 15: A430, 2001
 

Kim YK, Herlihy JT. Protective effects of sodium nitroprusside (SNP) on ischemia-reperfusion (IR) injury. FASEB J. 14: A684, 2000
 

Lee J, Yu BP, Herlihy JT. Modulation of cardiac mitochondrial membrane fluidity by age and calorie intake. Free Rad. Biol. Med. 26: 260-265, 1999.

Kelly GR, Herlihy JT. Food restriction alters the age-related decline in cardiac beta-adrenergic responsiveness. Mech. Ageing and Dev. 103: 1-12, 1998
 

Galvan V and Roizman B. (1998) Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. Proc. Natl. Acad. Sci. USA 95:3931-36.

 

Klebanov S  Herlihy, JT. Effect of life-long food restriction on cardiac myosin composition. J. Gerontol. 52A:B184-B189, 1997.
 

Klebanov S, Herlihy JT Freeman GL. Effect of long-term food restriction on cardiac mechanics. Am. J. Physiol. 273:H2333-H2342, 1997.
 

Kim JD, Yu BP, McCarter JM, Lee SY, Herlihy JT. Exercise and diet modulate cardiac lipid peroxidation and antioxidant defenses. Free Radicals in Biol. & Med. 20:83-88, 1996.

 

Lin A, Pulliam D, Sathyaseelan D, Halloran JJ, Burbank RR, Hussong SA, Bresnen A, Soundararajan A, Muir E, Duong TQ, Viscomi C, Zeviani M, Richardson AG, Van Remmen H,  Fox PT, Galvan V (2013) Decreased Mitochondrial Function With Surf1 Deficiency Enhances Brain Metabolism and Cognition in Mice. J Cereb Blood Flow Metab. Jul 10. PMID: 23838831.