Selected Publications

Fujikawa T, Castorena CM, Pearson M, Kusminski CM, Ahmed N, Battiprolu PK, Kim KW, Lee S, Hill JA, Scherer PE, Holland WL, Elmquist JK. SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise. eLife. 2016; 5. PMID: 27874828

Fujikawa, T. *, and Coppari, R. *, Living without insulin: the role of leptin signaling in the hypothalamus. Front Neurosci, (2015) 9, 108. *co-corresponding author

Williams, K.W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E.D., Deng, Z., Gao, Y., Liu, T., Sohn, J.-W., Jia, L., Fujikawa, T., Kohno, D., Sccotte, M., Lee, S., Lee, S., Sun, K., Chang, Y., Scherer, P.E., and Elmquist, J.K., Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell metabolism, (2014) 20, 471-482.

Fujikawa, T. * and Coppari, R. *, Hypothalamic-mediated control of glucose balance in the presence and absence of insulin. Aging, (2014) 6, 92-97. *co-corresponding author

Asterholm, I.W., Rutkowski, J.M., Fujikawa, T., Cho, Y.R., Fukuda, M., Tao, C., Wang, Z.V., Gupta, R.K., Elmquist, J.K., and Scherer, P.E., Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia, (2014) 57, 1209-1218.

Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 2013 Sep 3;18(3):431-44. doi: 10.1016/j.cmet.2013.08.004. PubMed PMID: 24011077; PubMed Central PMCID: PMC3890693.

Fujikawa, T., Berglund, E.D., Patel, V.R., Ramadori, G., Vianna, C.R., Vong, L., Thorel, F., Chera, S., Herrera, P.L., Lowell, B.B., Elmquist, J.K., Baldi, P., and Coppari, R., Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell metabolism, (2013) 18: p.431-444

Choi, Y.H.*, Fujikawa,T.* (co-first author), Lee, J., Reuter, A., and Kim, K.W., Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis. Front Neurosci, (2013) 7: p. 71.

Yamada, H., Iwaki, Y., Kitaoka, R., Fujitani, M., Shibakusa, T., Fujikawa, T., Matsumura, S., Fushiki, T., and Inoue, K., Blood lactate functions as a signal for enhancing fatty acid metabolism during exercise via TGF-beta in the brain. J Nutr Sci Vitaminol (Tokyo), (2012) 58(2): p. 88-95.

Ramadori, G., Fujikawa, T., Anderson, J., Berglund, E.D., Frazao, R., Michan, S., Vianna, C.R., Sinclair, D.A., Elias, C.F., and Coppari, R., SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell metabolism, (2011). 14(3): p. 301-12.

Miyaki, T., Fujikawa, T., Kitaoka, R., Hirano, N., Matsumura, S., Fushiki, T., and Inoue, K., Noradrenergic projections to the ventromedial hypothalamus regulate fat metabolism during endurance exercise. Neuroscience, (2011) 190: p. 239-50.

Kitaoka, R., Fujikawa, T., Miyaki, T., Matsumura, S., Fushiki, T., and Inoue, K., Increased Noradrenergic Activity in the Ventromedial Hypothalamus during Treadmill Running in Rats. J Nutr Sci Vitaminol (Tokyo), (2010) 56(3): p. 185-90.

Fujikawa, T., Fujita, R., Iwaki, Y., Matsumura, S., Fushiki, T., and Inoue, K., Inhibition of fatty acid oxidation activates transforming growth factor-beta in cerebrospinal fluid and decreases spontaneous motor activity. Physiology & behavior, (2010) 101(3): p. 370-5.

Fujikawa, T., Chuang, J.C., Sakata, I., Ramadori, G., and Coppari, R., Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci U S A, (2010) 107(40): p. 17391-6.

Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J., Morgan, D.A., Mostoslavsky, R., Stuart, R.C., Perello, M., Vianna, C.R., Nillni, E.A., Rahmouni, K., and Coppari, R., SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell metabolism, (2010) 12(1): p. 78-87.

Ramadori, G., Gautron, L., Fujikawa, T., Vianna, C.R., Elmquist, J.K., and Coppari, R., Central administration of resveratrol improves diet-induced diabetes. Endocrinology, (2009) 150(12): p. 5326-33.

Matsumura, S., Shibakusa, T., Fujikawa, T., Yamada, H., Matsumura, K., Inoue, K., and Fushiki, T., Intracisternal administration of transforming growth factor-beta evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells. American journal of physiology. Regulatory, integrative and comparative physiology, (2008) 294(1): p. R266-75.

Matsumura, S., Shibakusa, T., Fujikawa, T., Yamada, H., Inoue, K., and Fushiki, T., Increase in transforming growth factor-beta in the brain during infection is related to fever, not depression of spontaneous motor activity. Neuroscience, (2007) 144(3): p. 1133-4o.

Fujikawa, T., Matsumura, S., Yamada, H., Inoue, K., and Fushiki, T., Transforming growth factor-beta in the brain enhances fat oxidation via noradrenergic neurons in the ventromedial and paraventricular hypothalamic nucleus. Brain Res, (2007) 1173: p. 92-101

Fujikawa, T., Castorena, C.M., Pearson, M., Kusminski, C.M., Ahmed, N., Battiprolu, P.K., Kim, K.W., Lee, S., Hill, J.A., Scherer, P.E., Holland, L.W., and Elmquist, K.J., SF-1 Expression in the Hypothalamus is Required for Beneficial Metabolic Effects of Exercise. eLife, (2016) Nov 22;5

Anderson, G.A., Ramadori, G., Ioris, M.R., Galiè, M., Berglund, D.E., Coate, C. K., Fujikawa, T., Pucciarelli, S., Moreschini, B., Amici, A., Andreani, C., and Coppari, R., Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Molecular metabolism, (2015) 4, 846-56.