Jean C. Bopassa, Ph.D.
Mitochondria and Cardioprotection - Our general research interest is to investigate the role of mitochondria in cardio-protective effect of hormones against ischemia/reperfusion injury and heart failure. The kind of injury occurring in many clinical conditions, such as heart transplant, stroke, cardiac bypass, and coronary stenting after acute myocardial injury. Our research is focused to determine the molecular mechanism involved in cardio-protection induced by both acute and chronic administration of hormones (estrogen, in particularly). Using both pharmacological and genetic approaches, we are interested to understand the role of mitochondrial signaling (mitochondrial permeability transition pore (mPTP) opening) in estrogen-induced cardio-protective effect against ischemic myocardial injury and heart failure.